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Precision Medicines Against
LIpid-MEdiated Targets

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At Lime, we are inventing breakthrough lipid-targeting therapeutics using our novel drug discovery platform.

Lime Therapeutics is a fast-growing biotechnology company focused on making a difference for patients. We are a spinout company developing new technology invented at Memorial Sloan Kettering Cancer Center, and are using our breakthrough LipidSense™ platform to hunt for novel targets and create new drugs that modulate aberrant lipid metabolism in many forms of cancer, metabolic diseases, lysosomal storage diseases, and neurodegenerative disorders.

Intro
Leadership

Leadership

Team

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Scientist

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Scientific Advisory Board

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Robert Schwartz, MD, PhD

Weill Cornell Medicine

Matthew
Vander Heiden, MD, PhD

Massachusetts Institute of Technology (MIT)

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Rushika Perera, PhD

University of California,
San Francisco

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Tuomas Tammela, MD, PhD

Memorial Sloan Kettering Cancer Center

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Xuejun Jiang, PhD

Memorial Sloan Kettering Cancer Center

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Francis Tavares, PhD

ChemoGenics BioPharma

Business Advisors

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Robin Mansukhani

CEO, Deciduous Therapeutics

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Jeff Hatfield, MBA

Chairman of the Board of Directors, Vividion Therapeutics and ROME Therapeutics

Team
SAB
Biz Advisors
Technology

Technology

Creating Lipid-Altering Therapeutics

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Lipid dysfunction is a hallmark of a broad range of diseases such as cancer, metabolic diseases, lysosomal storage diseases, and neurodegenerative disorders. Despite this, efforts to hunt for lipid-mediated targets and create novel therapies have remained elusive due to lack of technology. 

 

We've changed the game with the invention of an ultrasensitive lipid detection technology. LipidSense is a high-throughput screening platform that monitors lysosomal lipid flux in real time in live cells, in a high-throughput screening format, and in live animals. 

 

We can tell within seconds whether a particular therapy changes lipid flux. We are utilizing this platform to discover drugs that can alter cancer's access to lipids or restore lysosomal lipid function in metabolic diseases and neurodegenerative disorders.

Ultimately, we are exploring therapeutic opportunities to touch the lives of 100 million patients.

Publications

A Carbon Nanotube Optical Reporter Maps Endolysosomal Lipid Flux.  

Prakrit V. Jena, Daniel Roxbury, et. al.  

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707631/

An optical nanoreporter of endolysosomal lipid accumulation reveals enduring effects of diet on hepatic macrophages in vivo.  

Thomas V. Galassi, Prakrit V. Jena, et. al.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6543545/

Long-term in vivo biocompatibility of single-walled carbon nanotubes

Thomas V. Galassi, et. al., and Daniel Heller

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202660/

Our Supporters

Thank you to those supporting our efforts to develop life-changing therapeutics (partial list):

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Case Western Reserve University

Alumni Venture Fund

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Little Green Bamboo

Invest together. Grow together.

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Kent Johnson, MBA

Former CFO, BioLegend

Inaki Berenguer, PhD, MBA

Life Extension Ventures

If interested in pursuing an investment opportunity, please reach out.

Our Supporters

Careers

We are not currently hiring, but send us your resume if you're interested in keeping in touch for future openings.

Careers
Contact

Contact

Headquarters

BioLabs@NYULangone

180 Varick St., Floor 6

New York, NY 10014

Inquiries

For any inquiries, please fill out the following form.

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Inquiries
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