
At Lime, we are inventing breakthrough lipid-targeting therapeutics using our novel drug discovery platform.
Lime Therapeutics is a fast-growing biotechnology company focused on making a difference for patients. We are a spinout company developing new technology invented at Memorial Sloan Kettering Cancer Center, and are using our breakthrough LipidSense™ platform to hunt for novel targets and create new drugs that modulate aberrant lipid metabolism in many forms of cancer, metabolic diseases, and neurodegenerative disorders.
Leadership
Scientific Advisory Board


Robert Schwartz, MD, PhD
Weill Cornell Medicine
Matthew
Vander Heiden, MD, PhD
Massachusetts Institute of Technology (MIT)

Rushika Perera, PhD
University of California,
San Francisco


Xuejun Jiang, PhD
Tuomas Tammela, MD, PhD
Memorial Sloan Kettering Cancer Center
Memorial Sloan Kettering Cancer Center
Business Advisors


Jeff Hatfield, MBA
Robin Mansukhani
CEO, Deciduous Therapeutics
Chairman of the Board of Directors, Vividion Therapeutics, and Harvard Blavatnik Fellow Advisor

Parul Chachra, PhD, MBA
Director, Innovaccer
Technology
Creating Lipid-Altering Therapeutics

Lipid dysfunction is a hallmark of a broad range of diseases such as cancer, metabolic diseases, and neurodegenerative disorders. Despite this, efforts to hunt for lipid-mediated targets and crate novel therapies have remained elusive due to lack of technology.
We've changed the game with the invention of an ultrasensitive lipid detection technology. LipidSense is a high-throughput screening platform that monitors lysosomal lipid flux in real time in live cells, in a high-throughput screening format, and in live animals.
We can tell within seconds whether a particular therapy changes lipid flux. We are utilizing this platform to discover drugs that can alter cancer's access to lipids or restore lysosomal lipid function in metabolic diseases and neurodegenerative disorders.
The primary indication for our lead drug candidate is non-small cell lung cancer. We are also exploring therapeutic opportunities for other types of cancer, NAFLD/NASH, and ALS. Taken together, these ailments represent an opportunity to touch the lives of over 100 million patients.
Publications
A Carbon Nanotube Optical Reporter Maps Endolysosomal Lipid Flux.
Prakrit V. Jena, Daniel Roxbury, et. al.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707631/
An optical nanoreporter of endolysosomal lipid accumulation reveals enduring effects of diet on hepatic macrophages in vivo.
Thomas V. Galassi, Prakrit V. Jena, et. al.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6543545/
Long-term in vivo biocompatibility of single-walled carbon nanotubes
Thomas V. Galassi, et. al., and Daniel Heller
News and Events
April 23, 2023
Lime Therapeutics Presents "Lightning Talk" at Advanced Science Research Center Symposium
February 28, 2023
Bristol Myers Squibb Awards Lime Therapeutics with a “Golden Ticket”
February 28, 2023
CWRU’s Alumni Venture Fund Brings Together Medical Student and
Lime Therapeutics, a Life Sciences Startup
February 3, 2023
CWRU Alumni Venture Fund Combines Capital with Education Featuring Lime CEO, Dr. Shardule Shah
January 10, 2023
Lime Therapeutics Wraps Up Successful JPMorgan Healthcare Week
December 15, 2022
2022 Most Disruptive Companies: Lime Therapeutics
Our Supporters
Thank you to those supporting our efforts to develop life-changing therapeutics (partial list):

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Case Western Reserve University
Alumni Venture Fund

Little Green Bamboo
Invest together. Grow together.


Kent Johnson, MBA
Former CFO, BioLegend
Inaki Berenguer, PhD, MBA
Life Extension Ventures
Dr. Parag and Dulari Doshi
Chicago Cardiology Institute
Dr. Mahendra and Nalini Maru
If interested in pursuing an investment opportunity, please reach out.