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Increasing Longevity by Unlocking Medicines Targeting Abnormal 
LIpid MEtabolism

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At Lime, we are inventing breakthrough lipid-targeting therapeutics using our novel drug discovery platform.

Lime Therapeutics is a fast-growing biotechnology company focused on making a difference for patients. We are a spinout company developing new technology invented at Memorial Sloan Kettering Cancer Center, and are using our breakthrough LipidSense™ platform to hunt for novel targets and create new drugs that modulate aberrant lipid metabolism in many forms of cancer, metabolic diseases, and neurodegenerative disorders.

Intro
Leadership

Leadership

Scientific Advisory Board

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Robert Schwartz, MD, PhD

Weill Cornell Medicine

Matthew
Vander Heiden, MD, PhD

Massachusetts Institute of Technology (MIT)

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Rushika Perera, PhD

University of California,
San Francisco

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Xuejun Jiang, PhD

Tuomas Tammela, MD, PhD

Memorial Sloan Kettering Cancer Center

Memorial Sloan Kettering Cancer Center

Business Advisors

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Jeff Hatfield, MBA

Robin Mansukhani

CEO, Deciduous Therapeutics

Chairman of the Board of Directors, Vividion Therapeutics, and Harvard Blavatnik Fellow Advisor

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Parul Chachra, PhD, MBA

X (Google)

Team
SAB
Biz Advisors
Technology

Technology

Creating Lipid-Altering Therapeutics

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Cancers feed off nutrients, such as lipids (fats). In addition, excess lipid buildup is a hallmark of neurodegenerative disorders. Despite this, efforts to target lipid metabolism in cancer and neurodegenerative disorders have remained elusive due to lack of technology. 

 

We've changed the game with the invention of an ultrasensitive lipid detection technology. LipidSense is a high-throughput screening platform that monitors lysosomal lipid flux in real time in live cells, in a well-plate format, and in live animals. 

 

We can tell within seconds whether a particular therapy changes lipid flux. We are utilizing this platform to discover drugs that can alter cancer's access to lipids or restore lysosomal lipid function in neurodegenerative disorders.

The primary indication for our lead drug candidate is non-small cell lung cancer. We are also exploring therapeutic opportunities for this and other drugs in our pipeline for pancreatic, colorectal, and kidney cancer. Collectively, these four cancers represent a $50B total addressable market (TAM) and 462,000 patients diagnosed annually in the US.

Publications

A Carbon Nanotube Optical Reporter Maps Endolysosomal Lipid Flux.  

Prakrit V. Jena, Daniel Roxbury, et. al.  

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5707631/

An optical nanoreporter of endolysosomal lipid accumulation reveals enduring effects of diet on hepatic macrophages in vivo.  

Thomas V. Galassi, Prakrit V. Jena, et. al.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6543545/

Long-term in vivo biocompatibility of single-walled carbon nanotubes

Thomas V. Galassi, et. al., and Daniel Heller

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202660/

News

Our Supporters

Thank you to those supporting our efforts to develop life-changing therapeutics (partial list):

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Case Western Reserve University

Alumni Venture Fund

Kent Johnson, MBA

Former CFO, BioLegend

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Little Green Bamboo

Invest together. Grow together.

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Dr. Parag and Dulari Doshi

Chicago Cardiology Institute

Inaki Berenguer, PhD, MBA

Life Extension Ventures

Dr. Mahendra and Nalini Maru

If interested in pursuing an investment opportunity, please reach out.

Our Supporters
Careers
Contact

Contact

Headquarters

BioLabs@NYULangone

180 Varick St., Floor 6

New York, NY 10014

Inquiries

For any inquiries, please fill out the following form.

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Inquiries
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